| Date |
|
Name |
|
Pos |
|
Status |
| Sat Apr 26 | | Lorenzo Booker | | RB | | traded (For 2008 4th-round pick) |
| Wed Apr 16 | | Richmond McGee | | P | | signed (Three-year contract) |
| Wed Apr 02 | | L.J. Smith | | TE | | re-signed/franchise player (One-year contract) |
| Tue Apr 01 | | Joselio Hanson | | CB | | signed (One-year contract) |
| Wed Mar 26 | | Kris Wilson | | TE | | signed/unrestricted free agent (Three-year contract) |
| Mon Mar 24 | | Rocky Boiman | | LB | | signed/unrestricted free agent (One-year contract) |
| Mon Mar 17 | | Dan Klecko | | RB | | signed/unrestricted free agent (Two-year contract) |
| Thu Mar 06 | | Takeo Spikes | | LB | | cut |
| Sat Mar 01 | | Chris Clemons | | DE | | signed/unrestricted free agent (Five-year contract) |
| Fri Feb 29 | | Kimo von Oelhoffen | | DT | | declared free agent |
| Fri Feb 29 | | Thomas Tapeh | | RB | | declared free agent |
| Fri Feb 29 | | Ian Scott | | DT | | declared free agent |
| Fri Feb 29 | | William James | | CB | | declared free agent |
| Fri Feb 29 | | Asante Samuel | | CB | | signed/unrestricted free agent (Six-year contract) |
| Fri Feb 29 | | Reno Mahe | | RB | | declared free agent |
| Thu Feb 28 | | Jevon Kearse | | DE | | cut |
| Thu Feb 28 | | J.R. Reed | | S | | re-signed (One-year contract) |
| Fri Feb 22 | | Bam Childress | | WR | | signed from Patriots |
| Tue Feb 19 | | L.J. Smith | | TE | | Designated franchise player |
| Tue Jan 08 | | Xzavie Jackson | | DE | | signed |
| Tue Jan 08 | | Jamal Jones | | WR | | signed/unrestricted free agent |
| Tue Jan 08 | | A.J. Schable | | RB | | signed/unrestricted free agent |
| Thu Jan 03 | | Jeremy Clark | | DT | | signed (Three-year contract) |
| Thu Jan 03 | | Jason Davis | | RB | | signed (Two-year contract) |
| Thu Jan 03 | | Bill Sampy | | WR | | signed (Three-year contract) |
| Thu Jan 03 | | Therrian Fontenot | | CB | | signed (Three-year contract) |
| Thu Jan 03 | | Michael Gasperson | | WR | | signed (Three-year contract) |
| Thu Jan 03 | | Ian Scott | | DT | | cut |
| Sun Dec 30 | | Jon Dorenbos | | C | | signed (five-year contract extension) |
| Wed Dec 26 | | Tanard Davis | | CB | | signed from Panthers |
| Wed Dec 26 | | Michael Gasperson | | WR | | cut |
| Fri Dec 21 | | William Kershaw | | LB | | practice squad addition |
| Fri Dec 21 | | Michael Gasperson | | WR | | Activated from the Practice Squad |
| Wed Dec 12 | | Ramiro Pruneda | | T | | practice squad addition |
| Sun Dec 09 | | Pat McCoy | | T | | cut |
| Thu Dec 06 | | Pat McCoy | | T | | Activated from the Practice Squad |
| Wed Nov 28 | | Kyle Shotwell | | LB | | practice squad addition |
| Tue Nov 13 | | Erick Harris | | S | | practice squad deletion |
| Tue Nov 13 | | Therrian Fontenot | | CB | | practice squad addition |
| Wed Nov 07 | | Xzavie Jackson | | DE | | practice squad addition |
| Wed Nov 07 | | Marcus Paschal | | S | | Activated from the Practice Squad |
| Wed Nov 07 | | Erick Harris | | S | | practice squad addition |
| Tue Oct 30 | | William Kershaw | | LB | | practice squad addition |
| Mon Oct 29 | | Akeem Jordan | | LB | | Activated from the Practice Squad |
| Mon Oct 29 | | Matt McCoy | | LB | | cut |
| Thu Sep 20 | | Jonathan Palmer | | T | | practice squad deletion |
| Thu Sep 20 | | Pat McCoy | | T | | practice squad addition |
| Wed Sep 19 | | Jonathan Palmer | | T | | practice squad addition |
| Wed Sep 19 | | J.R. Reed | | S | | re-signed |
| Wed Sep 19 | | Pat McCoy | | T | | cut |
| Wed Sep 19 | | Lee Vickers | | TE | | practice squad deletion |
| Tue Sep 11 | | J.R. Reed | | S | | cut |
| Tue Sep 11 | | Reno Mahe | | RB | | signed |
| Tue Sep 04 | | Jeremy Clark | | DT | | practice squad addition |
| Tue Sep 04 | | Jason Davis | | RB | | practice squad addition |
| Tue Sep 04 | | Marcus Paschal | | S | | practice squad addition |
| Tue Sep 04 | | Marques Murrell | | LB | | practice squad addition |
| Tue Sep 04 | | Michael Gasperson | | WR | | practice squad addition |
| Tue Sep 04 | | Lee Vickers | | TE | | practice squad addition |
| Tue Sep 04 | | Bill Sampy | | WR | | practice squad addition |
| Tue Sep 04 | | Akeem Jordan | | LB | | practice squad addition |
| Sun Sep 02 | | Kimo von Oelhoffen | | DT | | acquired from waivers |
| Sun Sep 02 | | J.R. Reed | | S | | acquired from waivers |
| Sat Sep 01 | | Nate Ilaoa | | RB | | cut |
| Sat Sep 01 | | Rashad Barksdale | | CB | | cut |
| Sat Sep 01 | | Dirk Johnson | | P | | cut |
| Sat Sep 01 | | Dedrick Roper | | LB | | cut |
| Sat Sep 01 | | Michael Gasperson | | WR | | cut |
| Sat Sep 01 | | Jeremy Bloom | | WR | | cut |
| Sat Sep 01 | | Lee Vickers | | TE | | cut |
| Sat Sep 01 | | Bill Sampy | | WR | | cut |
| Sat Sep 01 | | Jasper Harvey | | T | | cut |
| Sat Sep 01 | | Torrance Daniels | | LB | | cut |
| Sat Sep 01 | | Erick Harris | | S | | cut |
| Sat Sep 01 | | C.J. Gaddis | | S | | cut |
| Sat Sep 01 | | Jeremy Cain | | LB | | cut |
| Sat Sep 01 | | Dustin Fox | | CB | | cut |
| Mon Aug 27 | | E.J. Cochrane | | K | | cut |
| Tue Aug 21 | | Jeremiah Trotter | | LB | | cut |
| Wed Jul 25 | | Kevin Kolb | | QB | | signed/draft choice (Four-year contract) |
| Sun Jul 22 | | Nate Ilaoa | | RB | | signed/draft choice (Four-year contract) |
| Sun Jul 22 | | Victor Abiamiri | | DE | | signed/draft choice (Four-year contract) |
| Thu Jul 12 | | Michael Gasperson | | WR | | signed |
| Tue Jul 10 | | Zach Tuiasosopo | | RB | | cut |
| Tue Jun 19 | | Mike Bartrum | | TE | | retired |
| Wed May 30 | | Rashad Barksdale | | CB | | signed/draft choice (Four-year contract) |
| Wed May 30 | | Brent Celek | | TE | | signed/draft choice (Four-year contract) |
| Fri May 25 | | C.J. Gaddis | | S | | signed/draft choice ((four-year contract)) |
| Thu May 24 | | Stewart Bradley | | LB | | signed/draft choice (Four-year contract) |
| Thu May 24 | | Tony Hunt | | RB | | signed/draft choice (Four-year contract) |
